Dr. Andrea Natale

Dr. Andrea Natale


Dr. Andrea Natale graduated summa cum laude in Medicine and Surgery and is board certified in Cardiovascular Disease and Clinical Cardiac Electrophysiology. He is the Executive Medical Director of the Texas Cardiac Arrhythmia Institute at St. David’s Medical Center in Austin, Texas, and the National Medical Director of Cardiac Electrophysiology for HCA Healthcare.

A dedicated researcher and a pioneer, Dr. Andrea Natale focuses on innovative advances in the treatment of atrial fibrillation. He pioneered a circumferential ultrasound vein-ablation system to correct atrial fibrillation and performed the procedure on the world’s first patients. He was the first electrophysiologist in the USA to perform percutaneous epicardial radiofrequency ablation, which is a treatment for people who fail conventional ablation. Andrea Natale also developed some of the current catheter-based cure strategies for rhythm disorders, such as the ablation of the posterior wall or isolation of the left atrial appendage, coronary sinus and superior vena cava for atrial fibrillation, homogenization of the scar for ventricular tachycardia, or ablation of the Purkinje system for ventricular fibrillation. Andrea Natale has advanced the field of cardiac electrophysiology with new techniques to improve long term results of electrophysiology procedures, such as high power short duration ablation augmented by the use of half-normal saline irrigation creating better and faster transmural lesions or the closure of persistent peri-device leaks with radiofrequency energy, vascular plugs, or coils in patients with incomplete left atrial appendage closure.

He has been and continues to be involved in many first-in-human trials to test investigational devices, such as ablation catheters with contact force sensing technology, three-dimensional intracardiac echocardiography ultrasound probes, and novel left atrial appendage closure devices. He has recently performed the first pre-clinical and clinical studies to develop and perfect ablation catheters utilizing a novel, groundbreaking ablation energy source known as irreversible electroporation. He has also performed the first cases in the USA.

Dr. Andrea Natale holds patents on several life-saving medical devices, including a device used to treat atrial fibrillation. Dr. Andrea Natale’s major research interests include Clinical Cardiac Electrophysiology, mechanisms of defibrillation, signal-averaging, ablation treatment of supraventricular arrhythmias, the effects of thrombosis on platelet aggregation, and TxA2 metabolites production in patients with unstable angina and post-myocardial infarction.

Dr. Andrea Natale has held faculty positions at a variety of prestigious universities, including Duke University, the Cleveland Clinic and Case Western Reserve, Stanford University as well as the Dell Medical School at the University of Texas at Austin.

Andrea Natale has been an invited speaker at hundreds of symposia and conferences around the world, and has authored numerous published articles on pacing and electrophysiology in high-impact peer-reviewed journals in addition to serving on the editorial boards of several major medical journals. Andrea Natale is the Editor-in-Chief of the prestigious Journal of Investigational Cardiac Electrophysiology, the longest running Journal in this highly specialized field of cardiology.

In his stellar career, Andrea Natale has received many accolades, among which the Cleveland Clinic Innovator of the Year for several years in a row, the Frist Humanitarian Award in 2012, the 2017 Eric N. Prystowsky Advocate for Patients Award, and more recently the prestigious Star of Texas that honors one individual each year for their outstanding contribution to healthcare in the state of Texas and nationally.

Andrea Natale is very passionate about teaching the future generation of cardiac electrophysiologists. Among the many national and international courses and meetings of which he is director, Andrea Natale is particularly proud of creating and expanding worldwide EPLive, a cutting edge, intensive meeting targeting practicing electrophysiologist as well as fellows in training and consists of four sections: AF ablation, VT ablation, Devices and new technologies. A panel of recognized experts provide commentary and discussion during both live and recorded cases.

EP Live was first successfully held in Austin, Texas in 2012, and subsequently held in Milan, Italy; Dubai, UAE; Bogota’, Colombia; Bengaluru, India. New EPLive meetings are being planned in other locations to respond to the demand of EP specialists around the world.

Awards & Recognitions


Board Certifications

  • American Board of Internal Medicine, Clinical Cardiac Electrophysiology, 2001
  • American Board of Internal Medicine, Cardiovascular Disease, 2000

Medical Education

  • Universita Degli Studi Di Firenze, MD, 1985


  • Universita Degli Studi Di Firenze, Internal Medicine, 1986


  • Università Cattolica Del Sacro Cuore, Cardiovascular Disease, 1989


  • University of Wisconsin, Electrophysiology, 1993
  • University of Western Ontario, Clinical Cardiac Electrophysiology, 1992
  • University of Western Ontario, Cardiovascular Disease, 1990